Sergio Parisse returns to captain Italy in their final RBS 6 Nations match against England at a sold-out Stadio Olimpico in Rome on Saturday.
The Azzurri number eight missed last weekend's 46-7 defeat away to Ireland with a thigh injury.
Parisse is one of three changes made by Italy coach Jacques Brunel to his starting XV with respect to the team that played in Dublin.
Alberto De Marchi drops to the bench and is replaced by Zebre's Matias Aguero at loosehead prop.
Treviso prop Lorenzo Cittadini comes in for the injured Martin Castrogiovanni. Robert Barbieri shifts back to the flanker position having taken Parisse's role as number eight against Ireland, leaving Paul Derbyshire to drop to the bench.
Also on the bench, Brunel has included uncapped Zebre player George Biagi as cover in the second row. Italy have lost all of their games in the competition so far and have never beaten England.
The Azzurri fell 19-15 to England in Rome two years ago and kept England from scoring a try in an 18-11 defeat in Twickenham in the last edition.
Italy team to play England: L McLean (Treviso), A Esposito (Treviso), M Campagnaro (Treviso), G Garcia (Zebre), L Sarto (Zebre), L Orquera (Zebre), T Tebaldi (Ospreys), M Aguero (Zebre), L Ghiraldini (Treviso), L Cittadini (Treviso), Q Geldenhuys (Zebre), M Bortolami (Zebre), J Furno (Biarritz), R Barbieri (Treviso), S Parisse (Stade Francais).
Replacements: D Giazzon (Zebre), M Rizzo (Treviso), A De Marchi (Treviso), G Biagi (Zebre), P Derbyshire (Treviso), E Gori (Treviso), T Allan (Perpignan), A Masi (Wasps).
Live television coverage of the RBS 6 Nations from 12:00 on Saturday 5 March (12:30 Italy v England, 14:45 Wales v Scotland, 17:00 France v Ireland) on RTÉ Two and RTE.ie (Ireland only). Live radio coverage of France v Ireland on Saturday Sport (14:00) on RTÉ Radio 1 and RTÉ.ie (Worldwide).