Edinburgh wing Dougie Fife will make his debut for Scotland after head coach Scott Johnson confirmed the Scottish back line to face Wales.
Johnson had delayed naming his backs due to injury concerns, but has now selected his full, starting XV.
Fife comes in on the wing for the Scots, with Max Evans on the other wing and Stuart completing the back three.
“We like Dougie’s size and his competitive edge,” said Johnson. “He chases everything, which I like, and he has shown really good glimpses playing for Edinburgh this season.”
Fife said he was ““absolutely delighted and can’t wait. The Millennium Stadium with the roof closed – I don’t think it could be much better to be honest.”
Alex Dunbar and Matt Scott are the Scottish centres, and Greig Laidlaw and Duncan Weir continue their half-back partnership.
As announced on Wednesday, the only change to the Scottish pack that started the 19-17 defeat to France on Saturday sees Ryan Wilson restored to the back-row in place of the injured Johnnie Beattie, with the experienced Alasdair Strokosch returning to provide cover on the bench.
Wales announced their team on Thursday, Warren Gatland making six changes to teh side that lost to England in the penultimate round of the championship.
Scotland team v Wales: 15 Stuart Hogg; 14 Dougie Fife, 13 Alex Dunbar, 12 Matt Scott, 11 Max Evans; 10 Duncan Weir, 9 Greig Laidlaw; 1 Ryan Grant, 2 Scott Lawson, 3 Geoff Cross; 4 Richie Gray, 5 Jim Hamilton, 6 Ryan Wilson, 7 Kelly Brown (Capt), 8 David Denton.
Replacements: 17 Ross Ford, 17 Alasdair Dickinson, 18 Euan Murray, 19 Tim Swinson, 20 Alasdair Strokosch.