Wales full-back Leigh Halfpenny will miss the rest of this season after dislocating his right shoulder during the 29-18 RBS 6 Nations defeat against England at Twickenham.
Halfpenny, who kicked all Wales' points with six penalties, was comfortably his team's best player.
But Wales head coach Warren Gatland revealed in his post-match press conference the extent of Halfpenny's injury.
Halfpenny, who is leaving Cardiff Blues in June to join French giants Toulon, appeared to suffer the injury when he tackled England centre Luther Burrell in the second half.
Burrell would have scored his second try of the game, but his foot hit the touchline in the process of touching down.
"Leigh has dislocated his shoulder," Gatland said.
"That will be Leigh's season over, which is disappointing for him."
Scarlets back Liam Williams will be favourite to replace Halfpenny in next Saturday's final Six Nations game against Scotland in Cardiff.
Scrum-half Rhys Webb also went off injured, suffering what appeared to be an ankle injury, but there was no immediate fitness update on him.
Gatland is due to announce his team to face Scotland on Tuesday.