Devin Toner will start for Ireland against England on Sunday after Iain Henderson was ruled out following the birth of his child.
The Leinster lock will earn his 70th cap in what is now the only change to the side that beat Wales last time out.
Connacht second-row Ultan Dillane has been promoted to the bench in the Ulsterman's absence.
The rest of the team remains as it was named by head coach Andy Farrell on Wednesday.
Ireland, who began the tournament with successive Dublin wins over Scotland and Wales, initially opted for an unchanged starting XV, before their plans were altered by the birth of Henderson's son.
Toner will make his first start since his shock omission from Joe Schmidt's World Cup squad and captain Johnny Sexton is delighted to have his experienced Leinster team-mate back.
"It's brilliant for him, he's bounced back really well. Obviously everyone has setbacks through their career and he had a big one at a bad time for him but he has bounced back well," said Sexton.
"You saw by the reception that he got against Scotland - I've never heard a crowd cheer so loud for a line-out win.
"We were giving him a bit of stick about it but it just shows what everyone thinks of him. All the lads are delighted for him."
Scrum coach John Fogarty said: "Faz (Andy Farrell) was speaking with Iain during the week to see how it would all turn out.
"They spoke a bit last night and this morning and it became clear this morning. We had planned during the week, in the eventuality that it would happen, that Dev is there.
"It's a big ask if he (Henderson) was to come straight in, he missed two sessions, so that bit of cohesion when he's an important person in our line-out and in our team. We're delighted for him, a little baby boy."
England also announced their starting line-up today, Manu Tuilagi returning at centre in one of four changes made by Eddie Jones.
Ireland: Jordan Larmour; Andrew Conway, Robbie Henshaw, Bundee Aki, Jacob Stockdale; Johnny Sexton (captain), Conor Murray; Cian Healy, Rob Herring, Tadhg Furlong, Devin Toner, James Ryan, Peter O'Mahony, Josh van der Flier, CJ Stander.
Replacements: Ronan Kelleher, Dave Kilcoyne, Andrew Porter, Ultan Dillane , Caelan Doris, John Cooney, Ross Byrne, Keith Earls.
Follow England v Ireland (kick-off 3pm) on Sunday via our live blog on RTE.ie/Sport and the News Now app or listen live on RTÉ 2fm. Highlights on Against the Head, Monday at 8pm on RTÉ2 and RTÉ Player.
