Leo Cullen has called upon a mixture of youth and experience as he welcomes Conference A rivals the Toyota Cheetahs to the RDS (KO 2.30pm).
A number of players released from the Ireland camp for this weekend are chosen by Cullen in his starting XV, while four Academy players also make the match-day 23.
Rob Kearney starts at full back with Fergus McFadden on the right wing and Dave Kearney - one of those released by Ireland Head Coach Andy Farrell - on the left.
In the centre Joe Tomane wears the number 12 jersey with Jimmy O'Brien outside him.Luke McGrath is partnered by Ciarán Frawley in the half backs.
In the front row Offaly man Peter Dooley is joined by Rónan Kelleher, who was of course recently capped by Ireland for the first time against Scotland, while Michael Bent makes a welcome return from injury at tight head prop.
Ross Molony is joined by captain Scott Fardy in the second row.
Finally in the back row, fresh from his Ireland debut last weekend, Max Deegan wears the number eight jersey with Rhys Ruddock at blind side and Will Connors selected at open side.
Leinster (team to play Cheetahs): Rob Kearney, Fergus McFadden, Jimmy O'Brien, Joe Tomane, Dave Kearney, Ciarán Frawley, Luke McGrath; Peter Dooley, Rónan Kelleher, Michael Bent, Ross Molony, Scott Fardy (C), Rhys Ruddock, Will Connors, Max Deegan.
Replacements: Seán Cronin, Michael Milne, Roman Salanoa, Ryan Baird, Scott Penny, Jamison Gibson-Park, Harry Byrne, Cian Kelleher.
Ireland internationals Ultan Dillane and Dave Heffernan have returned to the Connacht starting team to face Cardiff Blues at the Sportsground on Saturday (KO 7:35pm).
Ballina native Heffernan comes into a front row alongside props Paddy McAllister and Finlay Bealham. Dillane's inclusion sees him line up alongside Gavin Thornbury in the second row with Quinn Roux still unavailable through injury.
In the back row, Captain Jarrad Butler starts at number 8 with Paul Boyle and Colby Fainga’a at blindside and openside respectively. Kieran Marmion and Jack Carty continue as the half back pairing with Caolin Blade and Conor Fitzgerald available off the bench.
With Bundee Aki still unavailable due to international duty, Peter Robb and Kyle Godwin are selected as the midfield partnership. In the back three Tiernan O’Halloran is selected at full back with Matt Healy and John Porch on the wings.
Connacht (team to play Cardiff Blues): Tiernan O'Halloran, John Porch, Kyle Godwin, Peter Robb, Matt Healy, Jack Carty, Kieran Marmion; Paddy McAllister, Dave Heffernan, Finlay Bealham, Ultan Dillane, Gavin Thornbury, Paul Boyle, Colby Fainga’a, Jarrad Butler (C).
Replacements: Shane Delahunt, Denis Buckley, Dominic Robertson-McCoy, Joe Maksymiw, Eoin McKeon, Caolin Blade, Conor Fitzgerald, Tom Daly.
Louis Ludik has returned from injury and has been selected to start for Ulster when they face Ospreys at Liberty Stadium on Saturday (KO 5.15pm).
Ludik will start on the left wing and is joined in the back three by full-back Matt Faddes and Robert Baloucoune, who re-joins the Ulster squad following his involvement in the development group which trained alongside the Irish squad in the build-up to the Six Nations.
Stuart McCloskey has been released from the Ireland squad and is paired with Luke Marshall in midfield.
Billy Burns has also been released from international duties and will start at fly-half alongside David Shanahan who comes in to start at scrum-half.
Alan O’Connor will lead the side from the second row and is partnered with Kieran Treadwell. Matthew Rea and Sean Reidy – who both recently signed two-year contract extensions with the province – start in the back row alongside number eight, Marcell Coetzee.
Jack McGrath and Tom O’Toole, who are also part of Ireland’s Six Nations squad, are named among the forward reinforcements with John Andrew, David O’Connor and Jordi Murphy.
Ulster (team to play Ospreys): Matt Faddes, Robert Baloucoune, Luke Marshall, Stuart McCloskey, Louis Ludik, Billy Burns, David Shanahan; Eric O'Sullivan, Adam McBurney, Marty Moore, Alan O'Connor (C), Kieran Treadwell, Matthew Rea, Sean Reidy, Marcell Coetzee.
Replacements: John Andrew, Jack McGrath, Tom O'Toole, David O'Connor, Jordi Murphy, Jonny Stewart, Bill Johnston, Craig Gilroy.
Munster announced their team to host Southern Kings (tonight, 7.35pm) on Thursday, head coach Johann van Graan handing a first start to first-year academy man John Hodnett as the back-row forward makes his PRO14 debut.