George Ford and Owen Farrell will pair up from the start for the first time in 14 months when England host Ireland at Twickenham on Saturday.
Ford continues at out-half with captain Farrell starting at inside centre and lining up alongside Manu Tuilagi in midfield.
Former age-group international pairing Ford and Farrell last started a Test at 10 and 12 when England lost 23-12 to South Africa in Bloemfontein on June 16, 2018.
Jamie George, Joe Marler and Kyle Sinckler are named in the front row. Tom Curry and Sam Underhill return from injury to play in the back row alongside Billy Vunipola while George Kruis starts in the second row alongside Maro Itoje.
Mako Vunipola has been named as among the replacements following his recovery from long-term injury.
"We purposefully made the week short looking ahead to the World Cup where this might happen beyond our control," Eddie Jones said.
"It is the third of four games for us and come the 8th of September, when we get on the plane, we want to be ready to go. This is another step forward for us.
"This weekend we will be looking to gain more game fitness and testing different sorts of game strategies. We have a specific way of how we want to play and the focus is very much on ourselves."
England: Elliot Daly; Joe Cokanasiga, Manu Tuilagi, Owen Farrell, Jonny May; George Ford, Ben Youngs; Joe Marler, Jamie George, Kyle Sinckler; Maro Itoje, George Kruis; Tom Curry, Sam Underhill, Billy Vunipola.
Replacements: Luke Cowan-Dickie, Mako Vunipola, Dan Cole, Courtney Lawes, Mark Wilson, Willi Heinz, Piers Francis, Jonathan Joseph.