It was a tough day at the office for Pat Lam's Bristol Bears who collapsed in the second half to slump to a spectacular 35-13 Premiership defeat at Gloucester.

Ian Madigan had helped them into a 13-3 lead at half-time, kicking eight points to add to Luke Morahan’s 18th-minute try.

But it went off the rails on the turnaround as Gloucester, coached by former Ireland international David Humphreys, roared back with 32 unanswered points.

Charlie Sharples scored two of their tries, with ex-Munster man Gerbrandt Grobler, Matt Banahan and Ed Slater getting the others. Billy Twelvetrees kicked two penalties and two conversions.

Leicester Tigers interim coach Geordan Murphy was left to rue Will Spencer's red card as Wasps eventually broke his team's stubborn resistance to register a 41-35 victory at the Ricoh Arena.

Eight days after Bristol flanker George Smith was sent off for a dangerous tackle at Saracens that was subsequently rescinded by a disciplinary hearing, Tigers lock Will Spencer was dismissed in similarly contentious circumstances.

Spencer caught Tommy Taylor with a shoulder to the head and his afternoon was over, but in his defence he was dipping low to make the tackle against a player who stands six inches shorter.

Murphy shook his head at referee Ian Tempest's decision and Spencer trudged off, another victim of the game's zero-tolerance policy on high tackles in the hope of reducing instances of concussion.

The incident happened in first-half injury-time and despite being a man down for the remainder of a pulsating Gallagher Premiership clash, Leicester produced their finest moments to lead twice, with the outstanding George Ford instrumental in their comeback.

Jonny May's second try was dubious due to a forward pass by Ford but it set up a grandstand finish that was eventually settled by three penalties from Wasps full debutant Lima Sopoaga.

Leicester's sense of grievance was at least eased by their haul of two bonus points

In the Top 14 Dave Ryan helped Agen battle past Bordeaux-Bègles at Stade Armandie.

Agen earned their second home in on the bounce in an impressive 22-17 victory.

Cork prop Ryan was to the fore as Agen - guided by the steady boot of Jake McIntyre - closed out a fine success.

Paddy Butler and Sean Dougall suffered a tough 27-23 loss with Pau, who couldn't hold on against Clermont.

Lucas Rey's yellow was the turning point. It allowed Clermont to turn the screw when they trailed by 20-17.

Yohan Beheregaray touched down to put them ahead, Greig Laidlaw converted and he then tagged on a penalty to make it safe.

Simon Zebo bagged another try for Racing 92, who also fielded Donnacha Ryan, but they still came out the wrong side of a 30-17 scoreline against Toulouse.

Toulouse are still unbeaten and laid the platfoirm for this win with a string start.

Maxime Mermoz and Sofiane Guitoune crashed over to give them a 14-3 lead at the break.

Zebo and then Juan Imhoff did strike to give the Parisians hope but Thomas Ramos was unerring off the tee and kept Racing at arm's length. 

Paddy Jackson was on the bench for Perpignan's  37-10 loss to La Rochelle at at the Stade Marcel-Deflandre. 

Second-half tries from Kini Murimurivalu, Geoffrey Doumayrou and Hikairo Forbes killed it for the hosts who were lacklustre in victory.

Newly promoted Perpignan are rooted to the bottom of the table.