Kingman and Toronado are among a field of just five runners in the Qipco Sussex Stakes at Glorious Goodwood on Wednesday.
Since his narrow defeat in the 2000 Guineas at Newmarket in early May, the John Gosden-trained Kingman has claimed hugely impressive victories in the Irish Guineas and the St James's Palace Stakes at Royal Ascot to confirm himself the leading three-year-old miler in Britain and Ireland.
Toronado, last year's Sussex Stakes hero, made a winning return to action in the Queen Anne at the Royal meeting but as he is a year older than his major rival, he must concede 8lb in the latest edition of the 'duel on the Downs'.
Aidan O'Brien sends two challengers from Ireland in Darwin and War Command.
Darwin looks to have his work cut out having been beaten in the Group Three Minstrel Stakes at the Curragh less than a fortnight ago, while War Command won the Dewhurst as a juvenile, but has been well beaten in three starts this year.
The field is completed by another three-year-old in Charlie Appleby's Godolphin runner Outstrip.
He finished off well to finish third behind Kingman at Royal Ascot, but it would be a major surprise if he were to turn the tables.