Ireland captain Andrew Balbirnie savoured the momentous victory over England as "one we'll remember forever" after overcoming the world champions in a nail-biting conclusion at the Ageas Bowl.
Tons from Paul Stirling and Balbirnie in a 214-run stand in the third one-day international laid the foundations for a chase of 329, the same score Ireland reached in famously beating the same opponents at the 2011 World Cup.
But the Irish team were still left needing 50 from the final 33 deliveries when Balbirnie holed out for 113 - soon after Stirling had been run out for 142 - and there were plenty of nervy moments thereafter.
Harry Tector and Kevin O'Brien managed to get them over the line with seven wickets and one ball to spare. O'Brien was the hero of Bangalore nine years ago and he was fittingly the one to hit the winning run.
It was Ireland's second victory over England and the team's first on English soil, while Balbirnie reflected with pride that his team can now boast victories over both white-ball world champions, having toppled T20 kings, the West Indies, in January.
"We've beaten the T20 world champions in their own backyards and we've beaten the ODI champions," Balbirnie said.
"It's a huge win for us and this group. For the young guys to be involved in this series but to also be involved in a win like that is special and one we'll remember forever.
"I don't know if it's sunk in. Hopefully we've given the kids and the young generation a bit of a boost and something to strive towards."
Ireland's consolation win in the Royal London series, with England running out 2-1 winners, gets them off the mark in the ICC World Cup Super League, part of the qualification process towards India 2023.
Some squad members now face two weeks in quarantine, although those based in Northern Ireland do not face those measures.
Balbirnie joked: "Hopefully if the Government are watching they could let it slide for two weeks! It's going to be frustrating but that's just the way it's going.
"It's a strange situation but it's been a strange situation for four months and we've just got to do as we're told.
"It will be a strange two weeks but I'm sure I'll find a couple of books or I might watch this game four or five times."