Katie Taylor will attempt to unify the lightweight division with a bout against the IBF champion Victoria Bustos on 28 April in New York.
The fight is taking place on the undercard of Daniel Jacobs bout against undefeated Pole Maciej Sulecki.
It is Taylor's second defence of her WBA world title, won in Cardiff against Anahi Sanchez last October and defended against Jessica McCaskill in December.
Her 29-year Argentinian opponent Bustos has held the IBF belt since September 2013 and has successfully defended her title on six occasions since.
The announcement of Jacobs' opponent will come as a disappointment to Cork Gary Spike O'Sullivan, who thought he had agreed a deal to fight the former middleweight champion.
Taylor said facing Bustos was the next step towards collecting all the lightweight belts. Belgium's Delfine Persoon (WBC) and Brazilian Rose Volante (WBO) are the other title holders.
"Becoming unified champion is very important to me," she said.
"Last year was great but I’m not really one for looking back and it’s all about the next challenge.
"I believe that winning my first world title as a pro is just the start of it, I want to fight all the other champions and unify the Lightweight division.
"Bustos is one of the longest reigning champions in women’s boxing so I’m expecting a very tough fight.
"I’ve been back in training camp in Connecticut since the beginning of the month so the hard work has started and I’m excited to have the chance to win another World title.
"I got a great reception when I fought there last year so I’m really looking forward to boxing there again. It's a unification fight and the Barclays Center is a fitting venue for a big fight like that."
If screened, Taylor's fight would become the first women's bout to be shown in HBO's 45-year history of covering the sport.