Iranian President Hassan Rouhani has said the United States was isolated among its traditional allies in its confrontation with Iran, and that even Europe was siding with Tehran against the reimposition of US sanctions.
"It does not happen often that the US makes a decision and its traditional allies abandon it," Mr Rouhani told parliament in a speech carried live on state television.
Washington reintroduced sanctions against Iran's currency trade, metals and auto sectors in August after the US withdrawal from a multinational 2015 deal that lifted sanctions in return for limits on Iran's nuclear programme.
European countries have criticised the U.S. withdrawal from the accord and have been putting together a package of economic measures to help offset the U.S. pressures on Tehran, which have contributed to the economic volatility in the country.
US curbs on Iran's vital oil exports are set to come into force on 4 November.
Mr Rouhani was speaking at the start of a parliament session to discuss a cabinet reshuffle which includes a proposed new economy minister, academic Farhad Dejpasand, who is widely seen as a technocrat, and three other economy-linked ministers.
The proposed cabinet changes come as the government faces intense pressure over the economic instability mostly caused by the US sanctions.
The economy has markedly deteriorated in the past year,suffering rising inflation and unemployment, a slump in the rial currency and state corruption.
"A year ago no one would have believed ... that Europe would stand with Iran and against America," Mr Rouhani said.
"Russia, China, India, the European Union, and some African and Latin American countries are our friends. We have to work with them and attract investments," Mr Rouhani added.