A house fire in Pennsylvania killed 10 people including three children - with one volunteer firefighter saying all the victims came from his extended family.

Authorities said they were investigating the incident, and no official details were immediately available on the circumstances or origins of the fire in the borough of Nescopeck.

It is a small farming community along the Susquehanna River, about 190km north of Philadelphia.

Local television station WNEP reported that one of the local volunteer firefighters who responded, identified as Harold Baker, said he had family ties to everyone who was in the house.

"I couldn't get in there to save them. That is the biggest thing that has been on me. I couldn't get in there to save them," Mr Baker told WNEP, struggling to hold back his emotions.

"We pulled up, and the whole place was fully involved. We tried to get in to them, but there was no way to get in to them."

10 people perished in the fire at Nescopeck, Pennsylvania

Among those who died were his son, his daughter, three grandchildren, his father-in-law, his brother-in-law and his sister-in-law, he told the television news. "All lost," Mr Baker said.

Some of those in home were just visiting, he said, and 13 dogs lived in the home as well.

The blaze erupted at about 2.45am Eastern time yesterday, state police said.

The bodies of all 10 victims were found inside the ruins.

The ruins of the house after it was engulfed in flames

The dead included seven adults ranging in age from 18 to 79, along with three children, two boys aged five and six and a seven-year-old girl, according to state police.

Three adults made it out unharmed, police said in a statement.

Neighbour Mike Swank told WNEP he heard a pop and when he looked out the window the house was already engulfed in flames.