Claire Cronin, the woman nominated as the next US Ambassador to Ireland, is due to appear before the Senate Foreign Relations Committee for a confirmation hearing on Wednesday.
If members of the committee approve the appointment, her nomination will then be voted on by the full Senate.
In June, US President Joe Biden announced Ms Cronin as his nominee for the position of US Ambassador to Ireland.
She currently serves as a Representative and as Majority Leader in the state legislature of Massachusetts.
She is also a lawyer and campaigned for Mr Biden in Massachusetts during the 2020 presidential election.
When her nomination was announced, Ms Cronin said she was deeply honoured to be chosen.
"If confirmed, I look forward to serving as ambassador and working with our partners in Ireland on both the challenges and opportunities ahead of us," she said.
Minister for Foreign Affairs Simon Coveney said it was "very welcome news".
"We look forward to welcoming her to Ireland," he said.
It is not yet clear if President Biden will name a US Special Envoy to Northern Ireland.
In May, 25 members of the United States Congress wrote to the US President calling on him to appoint a Northern Ireland Envoy.