The Atlantic Philanthropies organisation, founded by Irish-American businessman Chuck Feeney, will cease operating on Wednesday.
The organisation set out its timeline for an end of operations in 2009 and made its final grant commitments at the end of 2016.
Since 1982 the Atlantic Philanthropies has awarded 6,500 grants worth more than $8bn.
The Republic of Ireland received $1.3bn in grants while $570m was allocated to projects in Northern Ireland.
Mr Feeney will sign the dissolution papers at his home in San Francisco on Wednesday.
The Atlantic Philanthropies has worked with educational institutions, health and elder care.
It has also campaigned for equals rights across the globe.
As well as Ireland, the organisation has operated in Australia, Cuba, Bermuda, South Africa, the US and Vietnam.