A second outbreak of Avian Influenza has been confirmed in a flock of broiler chickens in Co Monaghan.
On Saturday, the virus was detected in a commercial turkey flock in the same area.
The Department of Agriculture has said the second flock at a broiler breeder farm, which has confirmed positive for the virus, will also be depopulated.
It said that a 10 kilometre protection zone remains in place to try reduce the spread of the disease. The department is restricting the movement of poultry and poultry products to and from restriction zone.
It has also introduced requirements to house or confine all poultry or captive birds so that wild birds and other animals do not have access to them and also the application of particular bio-security measures for poultry and other captive birds, as well as a ban on the assembly of birds.
The Chair of the Irish Farmers' Association Poultry Committee said earlier that he is confident there will not be a shortage of turkeys for Christmas dinner, despite the culling of 30,000 birds as part the depopulation process.
Andrew Boylan, a broiler farmer based in Carrickmacross, said the virus has been detected in one farm in Co Monaghan and appears to be a relatively isolated case.
The department said that since the start of November, HPAI H5N1 has been confirmed by the department in 49 wild birds in counties Kerry, Donegal, Galway, Offaly, Roscommon, Tipperary, Wexford, Waterford and Longford under its AI surveillance programme.