Brexit, Northern Ireland, E3 visas and trade are all expected to be on the agenda when Taoiseach Leo Varadkar meets US President Donald Trump in Shannon.
Minister of State and Clare TD Pat Breen will be among those formally welcoming Mr Trump to Ireland as he steps off Air Force One when it lands at Shannon Airport tomorrow afternoon.
The US President will then hold a bilateral meeting with the Taoiseach at the airport.
Mr Varadkar will use the opportunity to highlight the reciprocal, two-way trading relationship that exists between the United States and Ireland.
The two leaders will also revisit some of the issues they discussed during their St Patrick's Day meeting at the White House in March.
While the meeting is taking place, it is understood First Lady Melania Trump will attend a cultural performance at the airport.
President Trump and his wife will then travel to the Trump International Golf Links and Hotel in Doonbeg, Co Clare.
On Thursday, President Trump will travel to France for a D-Day Commemoration and will return to his Doonbeg resort that evening, where a dinner - attended by Irish officials including Irish Ambassador to the US Dan Mulhall and the Government's special envoy to the US, Fine Gael TD John Deasy - will take place.
On Friday, President Trump is expected to play golf in Doonbeg before returning to the US later that day.