The wearing of masks in retail settings and on public transport is no longer mandatory from today.
Close contact rules have also changed for everyone, except healthcare workers.
Public health measures in schools - such and masks, pods and staggered arrival times - have also come to an end.
The move comes almost two years to the day that the first case of Covid-19 was confirmed in Ireland.
Many of those who were travelling into Dublin's O'Connell street this morning still opted to wear a mask.
"I've just been on the bus and everybody still seems to be wearing them but probably as time goes on people will stop. I will still wear mine though," one commuter said.
"To be honest I think I'll still be wearing mine, just because you are in such small spaces," another commuter told RTÉ News.
But one Luas commuter said he is going to put his mask in the bin from now on.
"I don't feel it's a problem anymore. It's best I put it in the rubbish bin," he said.
In retail settings, face coverings are no longer mandatory.
One shopper who was coming out of Spar on Upper O'Connell Street said she is not nervous about not wearing a face covering in shops.
"I wouldn't be nervous anymore now. I'm glad things are getting back to normal now. It's more personal now seeing everyone's face again," she said.
John Caulwell, owner of Spar in Upper O'Connell Street, said there has been a mixed response so far.
"It's been a mixture, some people are still wearing masks, some are not, it's mixed," he said.
Today, the Department of Health was notified of 2,277 PCR-confirmed cases of Covid-19. A total of 3,642 people registered a positive antigen test through the HSE online portal.
Weekend figures were also released today. Yesterday, saw 2,338 PCR cases and 2,819 antigen positives, while on Saturday, there were 3,635 PCR confirmed tests and 3,147 positive antigen tests.
As of 8am today, there were 610 patients with Covid-19 in hospital – of whom 47 are in ICU.
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Hospitality workers are also no longer required to wear a face covering and masks are no longer mandatory on public transport.
However, wearing a face covering is still advised under public health guidance.
Mask requirements will also remain in healthcare settings.
The rules on close contacts have also changed, so that if a person has no symptoms, they no longer need to test or isolate, regardless of their vaccination status.
Symptomatic close contacts are still advised to isolate.
Healthcare workers who have a confirmed case of Covid-19 in their home will need to take antigen tests and follow different guidance.