The Pro-Life Campaign group has said the upcoming referendum will effectively give politicians "exclusive power" to decide our abortion laws.
The Pro-Life Campaign group said experience shows that politicians breach this trust.
The group noted that a number of Government ministers have expressed concerns about the proposal to allow unrestricted terminations up to 12 weeks being passed in the Oireachtas if the referendum succeeds.
However, the group said today that repealing the Eighth Amendment will effectively lead to "abortion on demand in the short to medium term".
"Repealing the Eighth Amendment amounts to handing a blank cheque to politicians to decide what our abortion laws should be without ever having to consult the people again in a referendum," said the Pro-Life Campaign.
Professor William Binchy said people cannot be in favour of repeal without accepting the consequences of unrestricted abortions.
He said voting yes to repeal was yes to "abortion on demand in the short to medium term".
Caroline Simons said the legislation will be subject to amendment and time limits can be eroded and it is a distraction to concentrate on them.
The group said they were confident that the Eighth Amendment would be retained and they would hold a civilised, informative and factual campaign.
Meanwhile, Sinn Féin’s health spokesperson Louise O’Reilly said that politicians have a duty to be aware of the facts around the referendum.
"It is the duty of all politicians to be informed of all the facts surrounding the referendum to repeal the Eighth Amendment. It is not good enough to have a superficial knowledge of the issue.
"We cannot have situations, as there has been in recent weeks, where politicians make spurious claims only for medical professionals such as Dr Peter Boylan of the Royal College of Obstetrics and Gynaecologists to have to write letters or take to television to clear up these false claims.
"The same goes for campaign groups. They too have a duty of care to deal only in facts when it comes to this debate," said Ms O'Reilly.