French President Emmanuel Macron has named Élisabeth Borne as his new prime minister, the first woman to head the French government in over 30 years, the Élysée said in a statement.
The Élysée said that Ms Borne, who is currently serving as the country's labour minister, would now be charged with forming a government.
Outgoing French Prime Minister Jean Castex earlier handed his resignation to the president, part of a widely expected reshuffle to make way for a new government in the wake of Mr Macron's re-election in April.
The departure of Mr Castex, who was a surprise choice for the role in 2020, enables Mr Macron to reshape the cabinet ahead of crucial parliamentary polls in June.
The centrist president will need a legislative majority to push through his domestic agenda following his re-election, with a new left-wing alliance and the far right threatening to block his programme.
Speculation has been rife in recent weeks about Mr Castex's replacement, with Mr Macron indicating he wanted a woman with left-wing and environmental credentials.
Those criteria reflect his desire to focus on schools and health in the early part of his second term, as well as the climate crisis which he has promised to prioritise.
Ms Borne, 61, is seen as an able technocrat who can negotiate prudently with unions, as the president embarks on a new package of social reforms that risk sparking protests.
'Need lots of courage'
The last woman premier, Édith Cresson, told the Journal du Dimanche newspaper yesterday that French politics remained "macho" more than 30 years after she briefly headed the cabinet from May 1991 to April 1992 under president François Mitterrand.
"She'll need lots of courage," Ms Cresson said.
Mr Macron, 44, registered a solid victory in 24 April presidential polls against far-right leader Marine Le Pen, winning by 59 to 41%.
Ms Le Pen and defeated hard-left leader Jean-Luc Mélenchon are both eyeing comebacks in the parliamentary elections on 12 and 19 June that would give them the ability to thwart Mr Macron.
Mr Mélenchon recently persuaded the Socialist, Communist and Greens parties to enter an alliance under his leadership that unites the left around a common platform for the first time in decades.
Mr Castex had intended to resign immediately after the presidential election in line with French tradition, but was persuaded by Mr Macron to stay on while he lined up a replacement.
The 56-year-old from rural southwest France has a no-frills style and a strong regional accent which has endeared him to many French people.
He will mostly be remembered for his management of the latter stages of the Covid-19 pandemic, delivering regular TV briefings on infection figures, shutdowns and social distancing measures.