49 workers at the Kepak lamb abattoir in Co Carlow have been informed that the facility is to close in March.
In a statement, Kepak Group said the site at Hacketstown been operating on a two to three day week in recent years and the business lacked sufficient scale to be sustainable in the longer term.
It said staff would be offered alternative employment at its other Irish processing facilities.
Last month the company said that it was undertaking a review to examine the cost structures and the plant and business efficiencies at its Hacketstown site.
The group employs over 1,700 people in its six Irish manufacturing sites around the country.
"The group regrets that this is the outcome not only for the staff and their families directly employed there but for the entire community of suppliers and associated service providers who have loyally supported the business over the past 27 years," the company said this evening.