Pearson chief executive Marjorie Scardino will step down after 16 years at the company.
This potentially clears the way for her successor at the global educational and media group to sell the Financial Times newspaper.
The first female chief executive of a FTSE 100 company had previously declared that the famous pink-paged FT title would only be sold "over my dead body".
The FT Group also holds a 50% stake in the Economist.
Scardino will step down at the end of the year to be replaced by John Fallon, the chief executive of Pearson's international education division since 2008.
Analysts said the choice showed where the group's priorities lie and that the 50-year-old Fallon would now have to also focus on the large education business in the US, which has been hit by tight school budgets.
Both Bloomberg and Thomson Reuters have been linked with a purchase of the FT Group in the last year but analysts note that Pearson has a strong balance sheet and would only need to sell the FT if it needed the money for a large and transformational deal.
Although the FT Group has succeeded in growing digital sales and subscription revenues, a sale of the title would still fit with the group's wider strategy of moving away from volatile advertising revenues.
Investors could also question the future of the book group Penguin within the wider firm as some analysts believe it also fails to support the growth of the dominant education division.
Scardino, one of the longest serving bosses of a FTSE company, transformed a diverse set of assets into a successful global educational and media business.
"She navigated two recessions, one financial crisis, a dot com boom and bust and several waves of structural industry change," Pearson chairman Glen Moreno said.
"Not only are Pearson and Marjorie still around to tell the tale but over the past 16 years our profits have hit last year's all time high," he added.
During her tenure, Scardino led a string of major deals. In her early years she sold off such leisure attractions as Madame Tussauds and Alton Towers, stakes in BSkyB and investment bank Lazard before selling in more recent years a stake in Interactive Data Corp and a 50% stake in the FTSE International.
The numerous disposals have allowed it to expand its education and testing business around the world. The group has tripled sales to nearly £6 billion under Scardino's watch and grown profits more than three times to a record high of £942m in 2011.
The Pearson share price has risen by 88% since Scardino took over in 1997, compared with the FTSE All-share Media index which is up 8% in the same period.
Chairman Moreno said he did not see the new appointment as a signal for a change in strategy. But analysts warned that the new appointment could lead to further changes within senior management, if executives overlooked for the top job decide to move on.