160 new jobs are to be created in Limerick, Kildare, Offaly and Down following separate announcements today.
80 jobs are being created as a result of an expansion by the Teleflex Medical OEM company based at Annacotty in Limerick.
The company currently employs 143 staff and is involved in the manufacture of catheter and tubing devices to support large original equipment manufacturers in the medical technology sector.
The company is a subsidiary of Teleflex Incorporated, a leading medical device company headquartered in Pennsylvania in the US.
The expansion comes about as a result of growth from existing customers and new business opportunities.
Jerry Kiely, General Manager of Teleflex in Limerick said today's announcement reflects a long-term plan to expand production capabilities and improve their current facilities.
The expansion is being supported by IDA Ireland.
Minister for Jobs, Enterprise and Innovation Richard Bruton said 15 of the top 25 Medtech companies have operations in Ireland, and Ireland is Europe's largest exporter of medical devices, per capita.
He said he is looking at ways in which we can build on our strength in areas such as this to assist both multinationals and start-ups to expand and create more jobs.
Separately, Nua Healthcare is to create 40 new jobs in Kildare and Offaly.
Nua Healthcare is to open a residential assessment centre in Offaly, employing 15 people and catering for up to four children with Autism.
The company will also open a healthcare facility in Kilcullen, Co Kildare, creating at least 25 jobs.
The Kilcullen facility will cater for people with intellectual disabilities and problems associated with ageing, such as Alzheimer's disease or Dementia.
An insurance company based in Co Down is set to expand its operations with the recruitment of 20 new employees.
Hughes Insurance was also due to open a £2m extension to its headquarters in Newtownards today.