The HSE is encouraging people to think about how offering support may play a part in helping to prevent suicide.
The announcement comes on World Suicide Prevention Day, which is organised annually by the International Association for Suicide Prevention and the World Health Organization.
The HSE's National Director of Mental Health, Anne O'Connor, said: "This year's theme - 'Take a minute, change a life' - is about understanding and recognising that reaching out to someone can help to prevent suicide."
Ms O'Connor said that figures suggest a decreasing trend for deaths by suicide in Ireland in recent years.
However, she added that "every death by suicide is a tragic and devastating event that impacts on the lives of so many people.
"The prevention of suicide is a challenge, which all of us have to take on board," Ms O'Connor said.
The Minister of State for Mental Health, Jim Daly, has said that "as a society we need to de-stigmatise suicide and talk more openly about its causes and its impacts and how these can be prevented".
The HSE's website - yourmentalhealth.ie - contains information and practical tips on how to 'Take a minute, change a life'.