The Fatal Foetal Abnormalities Bill has been defeated in the Dáil.
The bill was rejected by 95 TDs and supported by 45.
The bill brought by Independents4Change TD Mick Wallace was deemed to be unconstitutional by the Attorney General.
A number of Independent TDs in the minority Government voted in favour of the bill after Taoiseach Enda Kenny stated that Cabinet members could have a free vote on the issue.
It is understood Independent Alliance Ministers Shane Ross, John Halligan and Finian McGrath voted in favour of the bill.
Five Fianna Fáil TDs also backed the bill: Robert Troy, Timmy Dooley, Niall Collins, Lisa Chambers and Fiona O'Loughlin.
Sinn Féin's Peadar Tóibín did not vote for the bill as he was absent from the Dáil.
A party spokesperson said Mr Tóibín was suffering the after-effects of a recent car crash and had called in this morning to say he was unwell.
The spokesman said that had he been present Mr Tóibín would have been obliged to support the measure.
He was disciplined by Sinn Féin in 2013 when he did not support the Protection of Life during Pregnancy Bill citing ethical objections.