The White House has confirmed Michelle, Malia and Sasha Obama will visit Dublin next week.
Mrs Obama and her children will arrive in Dublin on Monday, after introducing her husband at an event at the Waterfront Convention Centre in Belfast.
The first lady will visit Trinity College, where she will explore archives documenting the Obamas' Irish ancestry in the Old Library and view the Book of Kells.
Later in the day, Mrs Obama will meet the staff and families of the US Embassy and attend a special performance of Riverdance at the Gaiety Theatre.
On Tuesday morning, Mrs Obama will visit the Wicklow Mountains National Park before rejoining her husband as he travels to Berlin.
A garda spokesman said there will be a security operation and a traffic management plan in place in and around the Dublin 2 area on Monday and Tuesday, including rolling road closures.
Commuters and students are advised to give themselves extra time to travel around the city and use public transport where possible.
"Our aim is to ensure that any restrictions on traffic are kept to a minimum with the least amount of disruption possible," he said.
"We are particularly mindful of second and third level exams taking place in schools and colleges in Dublin city centre and we have liaised with local colleges and schools."
Kildare Street will be closed to through traffic from Sunday evening to Tuesday evening, but access to local premises, including the Dáil, will be facilitated.