A total of 245 people have been arrested in an international investigation of child pornography, US Immigration and Customs Enforcement said.
The agency's director, John Morton, said 123 child victims were identified during a five-week investigation, which ended in early December.
ICE and local authorities found 110 victims in 19 US states, while the others were living in six countries elsewhere.
The victims ranged in age from less than one to 17 years old. A total of 44 victims were living with their accused abusers.
Mr Morton declined to provide specific details about which foreign countries were involved, saying only that there were some cases in Mexico.
The investigation, dubbed "Operation Sunflower," was part of ICE's effort to find and rescue victims, and arrest abusers and people who make or transmit child pornography.
"We have to attack child exploitation relentlessly and together. There is no other way, there is no other answer," Mr Morton said.
"It is a wrong among wrongs. We are literally defending the defenceless."