Ryanair is to cut 30% of its flights at its Frankfurt Hahn base in Germany next summer.
The airline said its 2011 summer schedule will see its fleet at the airport cut from 11 to eight.
This will see flights falling to less than 400 each week from more than 500.
Ryanair said the move will result in the loss 150 Ryanair pilot and cabin crew jobs at the airport.
However, it said the staff affected will be offered the chance to re-locate to other Ryanair bases.
The airline claims the cuts will lead to the loss of 1,000 tourism-related jobs in total at Frankfurt Hahn.
The airline will also close nine routes from the German base to Agadir, Berlin, Gdansk, Gothenburg, Klagenfurt, Prague, Santiago, Seville and Wroclaw.
Another 15 routes will also suffer reduced frequencies.
Ryanair's Michael Cawley said 'the German government's €8 tourist tax will do significant damage to traffic and tourism in Germany next year'.