The distribution of the swine flu vaccine will begin tomorrow and should begin arriving in GPs surgeries from Monday.
However, the HSE says it is likely to be two weeks before the majority of GPs will have received the vaccine and that the public should bear this in mind.
Around 1,800 GPs have agreed to administer the vaccine.
A further 200 have sought clarification about indemnity.
The first round of vaccines will be made available for high risk groups which is defined as pregnant women and people with chronic illness aged between six months and 65.
It is estimated that there are about 410,000 people in that group, about 10% of the population
State Chief Medical Officer Dr Tony Holohan said adults will require just one dose of the vaccine but those under 14 will require two doses.
The HSE said they will monitor the roll out of the vaccination scheme and that if needed they will provide facilities for the vaccine to be administered.
The incidences of swine flu have increased to 97 cases per 100,000 population, up from 88 last week.
73 people were admitted to hospital this week bringing the total hospitalised with the illness to 302. 4
Three of those remain in hospital.
Five more people were admitted to intensive care this week bringing the total admitted to 25. 11 of those remain in intensive care.
43% of those admitted to hospital have an underlying illness and three quarters of this group are under 35.