The Brendan Gleeson and Don Cheadle-starring comedy-thriller The Guard has become the most successful independent Irish film in Irish box office history, grossing over €4.13m.

The John Michael McDonagh-written and directed film has also taken more at the Irish box office than international films such as The King's Speech, The Hangover 2, Transformers: Dark of the Moon and Pirates of the Caribbean: On Stranger Tides.

The Guard is screening in almost 200 cinemas in the US, has been in the Top 10 in the UK, Australia and New Zealand and will open in Germany, France, Italy and Holland later this year.

Commenting, director McDonagh said: "It's been extremely satisfying for me that such a hard-drinking, whoring, drug-taking, anti-authoritarian character as Sergeant Gerry Boyle has struck so resounding a chord with Irish and international audiences."

The film's producer, Ed Guiney, said: "This is a landmark film for Irish cinema and we are delighted to be part of it. It's brilliant that it has hit so big at home but it's also more important than ever that Irish film punches above its weight internationally – and it's case proven with The Guard."

James Hickey, Chief Executive, Irish Film Board, added: "We're delighted to see an Irish film compete successfully with major Hollywood blockbusters here in Ireland and also achieving a strong audience response worldwide.

"It's a testament to the local and the international appeal of Irish film and the quality of filmmaking in Ireland."