Grey's Anatomy is a medical drama about a group of surgeons working at Seattle Grace Hospital. The show centers around Meredith Grey (Ellen Pompeo) and her life as a third year resident at the hospital. In addition to her relationship with her neurosurgeon husband, Derek Shepherd (Patrick Dempsey), and best friend Cristina Yang (Sandra Oh), it also explores her relationships with her peers and the other doctors around her. Each episode dives into different medical cases and personal dramas of the doctors at Seattle Grace, with Dr. Richard Webber (James Pickens Jr.) at the helm of the surgical department.
The doctors of Seattle Grace are faced with the aftermath of last season's plane crash, as the fates of Meredith (Ellen Pompeo), Derek (Patrick Dempsey), Cristina (Sandra Oh), Mark (Eric Dane) and Arizona (Jessica Capshaw) all hang in the balance.