Booker prize-winner Kazuo Ishiguro's Never Let Me Go, JB Priestley's An Inspector Calls will replace Harper Lee's To Kill a Mockingbird and John Steinbeck's Of Mice and Men.
Maya Angelou's I Know Why the Caged Bird Sings has also been dropped. The American writer passed away yesterday, aged 86.
The changes were made in response to a UK Department for Education directive earlier this week urged that syllabuses should contain more British literature.
There have been angry protests over the decision, and a petition signed by more than 50,000 people has been launched by English teacher, Mary Stevens.
There are reports that the education secretary, Michael Gove, had personally intervened in the matter of the syllabus. Paul Dodd of the exam board OCR told The Sunday Times that Gove "really dislikes" the Steinbeck novel.
"It was studied by 90% of teenagers taking English literature GCSE in the past, "Dodd declared. "Michael Gove said that was a really disappointing statistic."
The changes are subject to approval by exam regulator Ofqual.