50 Cent will star in Spy, an upcoming comedy from Paul Feig.
According to The Hollywood Reporter, the rapper will play himself in the spy movie about a CIA analyst (Melissa McCarthy) who goes into the field for the first time.
The star-studded cast also includes Jude Law, Jason Statham, Rose Byrne, Bobby Cannavale, Miranda Hart and Nia Long.
Feig (Bridesmaids) will direct from a script he wrote and will produce the project alongside Jessie Henderson, Peter Chernin and Jenno Topping.
Spy will shoot in Budapest this April.
Jackson last year appeared in Escape Plan with Sylvester Stallone and Arnold Schwarzenegger and just wrapped The Prince, a crime movie starring Bruce Willis and John Cusack.