U2 are premiering their new single Invisible at the Super Bowl on Sunday, February 2.
The song will air as part of a Bank of America advertisement for Bono's (RED) campaign, which promotes HIV/AIDS prevention worldwide.
Invisible will then be made available for free on iTunes for the first 24 hours following the Super Bowl, with Bank of America donating $1 for each download until a figure of $2 million is reached.
The proceeds from the charity effort will go to the Global Fund to Fight AIDS, Tuberculosis and Malaria.
Bono announced the news, saying: "Bank of America coming on as a (RED) partner to help the Global Fund's efforts to eliminate AIDS is great news.
"It's the kind of game-changing influence that will not just deliver millions of dollars but raise consciousness and keep public pressure on putting an end to this devastating pandemic which has already taken the lives of 35 million people."
Bono added: "And just in . . . the bank's commitment of $10 million has resulted in the Gates Foundation, SAP and Africa's Motsepe Family matching for a total of $22 million (£13.2m). Incredible!"
Super Bowl XLVIII, which will see the Denver Broncos compete against the Seattle Seahawks, airs on Fox from MetLife Stadium in East Rutherford, New Jersey.
Invisible is the first single from U2's next studio album.