Luca Calvani has been cast to play the villain in the film adaptation of the 1960s television series.
The To Rome With Love actor will star opposite Henry Cavill and Armie Hammer in the film that is being directed by Guy Ritchie.
The Man from U.N.C.L.E. follows the adventures of two agents from the United Network Command for Law Enforcement. The agents were originally played by Robert Vaughan and David McCallum in the series.
Hugh Grant, Alicia Vikander, Jared Harris and Elizabeth Debicki will also star.
The Man from U.N.C.L.E. is currently filming in the UK, Rome and Naples.