Matt Prater kicked the longest field goal in NFL history and Peyton Manning threw four touchdown passes as the Denver Broncos eased to a 51-28 victory over the Tennessee Titans.
In temperatures of -10C, Prater launched the ball from 64 yards to beat the previous record, held jointly by a number of players, by a single yard.
Along with his four TD passes, Manning completed a franchise-record 39 passes from 59 attempts for a total of 397 yards to help the Broncos confirm their play-off spot.
Drew Brees matched Manning's effort with four touchdown passes of his own to help the New Orleans Saints go clear at the top of the NFC South with a 31-13 win over the Carolina Panthers.
The Panthers had not conceded more than two touchdowns in any game this season but Brees found Marques Colston twice in the second quarter, then picked out Jimmy Graham for a third before half-time.
Brees - who threw for 313 yards in total, taking his career total over 50,000 - and Graham combined again in the fourth.
Tom Brady threw two touchdown passes in the final 61 seconds as the New England Patriots escaped with a 27-26 win over the Cleveland Browns.
Brady found Julian Edelman on a two-yard pass to cut the deficit to 26-21 and Kyle Arrington then recovered the onside kick.
Brady marched his side down the field and found Danny Amendola on a one-yard pass which proved decisive when Billy Cundiff missed a 58-yard field goal.
Only a potentially serious leg injury to tight end Rob Gronkowski soured the Pats' win.
Washington Redskins coach Mike Shanahan's job was thrust into further question after he watched his side thumped 45-10 at home to the Kansas City Chiefs.
Kansas City ended their three-game losing run without much resistance after they scored on their first four possessions.
Redskins quarterback Robert Griffin III was also sacked five times on a miserable afternoon for coach Shanahan, whose position had been under the spotlight following a season that has now seen his side go 3-10.
By contrast, the Chiefs sealed a 10th win of the season to keep the pressure on the Broncos in the AFC West.
LeSean McCoy rushed for a franchise-best 217 yards, including touchdowns of 57 and 40 yards, as the Philadelphia Eagles beat the Detroit Lions 34-20 in blizzard conditions.
Heavy snow greeted the players but it was the Eagles who handled it best to improve to 8-5.
Joe Flacco's nine-yard touchdown pass to rookie Marlon Brown with four seconds left handed defending champions the Baltimore Ravens a 29-26 win over the Minnesota Vikings, who saw star running back Adrian Peterson injured.
Victory kept the Ravens in touch for a wildcard berth with the Cincinnati Bengals likely to win the AFC North.
The Benglas remained two games clear as they maintained their perfect home record with a 42-28 win over the Indianapolis Colts.
The Miami Dolphins stayed in the thick of play-off contention with a 34-28 win at the Pittsburgh Steelers.
Charles Clay caught two touchdowns, including a decisive 12-yard pass from Ryan Tannehill with just under three minutes left.
The Green Bay Packers snapped a five-game winless run 22-21 at home to the Atlanta Falcons while the New York Jets were 37-27 winners over the Oakland Raiders.
Rookie Mike Glennon threw a pair of touchdown passes to lead the Tampa Bay Buccaneers to a 27-6 win over the Buffalo Bills.
The Seattle Seahawks missed the chance to clinch the NFC West as Phil Dawson's field goal with 26 seconds to play handed the San Francisco 49ers a 19-17 win.
The San Diego Chargers beat the New York Giants 37-14 and the Arizona Cardinals were 30-10 winners over the St Louis Rams.