Rafael Nadal will not defend his US Open title this month after failing to recover fully from a wrist injury.
The world number two revealed the news on his official Facebook page on Monday afternoon.
The 28-year-old left-hander sustained the injury during practice last month and has been training with a cast on his right wrist, forcing him to miss the Rogers Cup in Toronto and last week's Cincinnati Open.
"I am very sorry to announce I won't be able to play at this year's US Open a tournament on which I've played 3 consecutive finals in my last participations," Nadal wrote.
"I am sure you understand that it is a very tough moment for me since it is a tournament I love and where I have great memories from fans, the night matches, so many things...
"Not much more I can do right now, other than accept the situation and, as always in my case, work hard in order to be able to compete at the highest level once I am back."
Having to deal with the disappointment of injury is nothing new for the Mallorcan.
He was unable to defend his Wimbledon title back in 2009 when his problematic knees caused him to breakdown, with the same problem manifesting itself in 2012.
He missed the US Open in that year too and was absent from the court for the best part of nine months before returning to win the French Open and the US in 2013.
A fourteenth grand slam title followed on the clay of Roland Garros in May this year, but his pursuit of Roger Federer's record 17 trophies will go on hold until the Australian Open in January at least.