Defending champion Rafael Nadal, Wimbledon champion Andy Murray and Australian Open champion Stanislas Wawrinka are in the same half of the French Open draw.
Eight-time champion Nadal will play American wild card Robby Ginepri in the first round, and could meet exciting young Austrian Dominic Thiem in the second round.
Should they both progress, Murray and Wawrinka would meet in the quarter-finals for a potential match against Nadal in the semi-finals.
Scotland’s Murray will take on Kazakhstan's Andrey Golubev in the first round in what is his first French Open match for two years.
The Wimbledon champion, seeded seventh, missed the tournament last year because of the back problems that eventually led to him undergoing surgery last September.
Should Murray get past the Kazakh, he will play either Australia's Marinko Matosevic or German-Jamaican Dustin Brown. Talented German Philipp Kohlschreiber is the first seed he could face in round three.
In the bottom half, second seed Novak Djokovic meets Joao Sousa of Portugal while Roger Federer, a potential semi-final opponent, plays Lukas Lacko.
In the women's draw, reigning champion Serena Williams plays France's Alize Lim, her friend from Patrick Mouratoglou's academy.
Williams could play sister Venus in the third round but she has a very tricky opener against 17-year-old Swiss Belinda Bencic, last year's junior champion.
Serena is also seeded to potentially face a rematch with Maria Sharapova, who she beat in last year's final, in the last eight.
The women's second seed is Australian Open champion Li Na, who meets Frenchwoman Kristina Mladenovic in round one.
Play at the second grand slam of the year begins at Roland Garros on Sunday.