Novak Djokovic tops the men's seedings for this year's US Open after the tournament organisers followed the world rankings.
Defending champion Rafael Nadal and five-time winner Roger Federer second and third respectively.
Djokovic has lost just two of his 59 matches this season, the latest coming when he withdrew from his Western & Southern Open final against Murray in Cincinnati while trailing 6-4 3-0.
He has won nine titles along the way and will have high hopes of adding to his three grand slam titles to date with his first Flushing Meadows crown, having been runner-up to Nadal last year and Federer in 2007.
Mardy Fish is the highest-seeded home player at number eight, with Andy Roddick at 21 and John Isner 28.
The women's seedings also follow the rankings save for the withdrawal of world number three Kim Clijsters and number 30 Alisa Kleybanova, leaving Caroline Wozniacki as top seed.
Russians Vera Zvonareva and Maria Sharapova follow with Victoria Azarenka of Belarus completing the top four, while Wimbledon and French Open champions Petra Kvitova and Li Na follow in fifth and sixth.
Serena Williams is seeded 28th after the United States Tennis Association opted not to elevate her, while sister Venus is a dangerous unseeded threat.
The championships begin on Monday and run until September 11, with the draw to be made tomorrow.