Shamrock Rovers v Cork City, Tallaght Stadium, 7pm
The sides have already met four times this season, twice in the league and twice in the Setanta Sports Cup semi-final.
There have been three draws, with Rovers claiming the only win - a 2-1 victory at Turner’s Cross in June.
Rovers are in fifth place in the table, six points ahead of Cork, so Stuart Ashton’s side can close the gap with a win.
Rovers have Jason McGuinness and Mark Quigley both suspended for the tie.
Danny Ledwith is also out of the game due to a hamstring injury.
There are doubts over Ronan Finn (groin), Conor McCormack (knee), Stephen Rice (ankle) and Karl Sheppard (abdomen), who will all be assessed before the game.
Cork come into the game on the back of three league wins but must plan without Ciarán Kilduff who misses the game due to the terms of his loan move from Shamrock Rovers.
Danny Murphy returns following a one match suspension but defenders Kevin Murray (groin) and Darren Dennehy (foot) remain sidelined through injury.
Bohemians v Sligo Rovers, Dalymount Park, 7.45pm
Bohemians go into this game looking to match their season-best run of three matches unbeaten and, depending on results elsewhere, a draw or win could widen the gap between Bohs and the two teams below them in the league table.
The two games so far this season have resulted in a scoreless draw at the Showgrounds and a 3-0 win for Sligo at Dalymount.
Bohs have Dave Mulcahy back from suspension but David Scully (ankle) remains out and new signing Neil Yadolahi has been added to the squad.
Sligo have lost just once to a team in the bottom half of the table this season and Joseph Ndo is poised to make his 100th league appearance for the Bit O’Red.
Sligo’s squad is unchanged from Tuesday’s 1-1 draw with Drogheda as Pascal Millien is on international duty with Haiti.
Limerick v St Patrick's Athletic, Thomond Park, 7.45pm
Liam Buckley’s side have lost just one of their last 22 Premier Division outings and that was with ten men at Dundalk in June while Limerick come into the game on the back of a four-match losing streak in all competitions but still determined to finish in the top six.
St Pat’s have won both meetings of the sides this season, recording a 1-0 victory at Thomond Park and a 3-0 win at Richmond Park.
Limerick’s long-term absentees Stephen McGann (foot) and Shane Tracy (knee) are again unavailable, but manager Stuart Taylor is hopeful that Brian O’Callaghan and Pat Purcell will be available.
Shaun Kelly is suspended but Rory Gaffney has served his ban and Danny Galbriath has recovered from the injury which forced him out last week.