Damien Duff has retired from international action ahead of the 2014 World Cup qualifying campaign.
The 33-year-old, who captained the national side when winning his 100th cap against Italy at Euro 2012, has been a regular in the side since making his debut against the Czech Republic in 1998.
Shay Given, the Republic of Ireland’s most-capped player of all time, announced his retirement earlier this month after an international career that saw him make 125 appearances for the Boys in Green.
Duff told the Football Association of Ireland's website: "I found it very difficult to make this decision, not least for the respect in which I hold Giovanni Trapattoni.
"I have enjoyed so many good times in the green jersey and want to thank everyone involved, especially the fans for making the last 14 years so special.
"I want to wish Giovanni, Marco [Tardelli] and everyone involved with the Irish team every success for the future and will be supporting them every step of the way."
Manager Giovanni Trapattoni said: "Damien will be missed by us and by Irish fans everywhere.
"He was immensely skilful and a great example to the players who come after him. I give him my warmest best wishes for his future career."
Duff joined Blackburn as a trainee in 1996 and stayed until 2003, before spending three seasons at Chelsea and Newcastle before signing for Fulham in 2009.
John Delaney, FAI chief executive added: "I have no doubt that Damien Duff will go down in history as one of Ireland's greatest ever players.
"He has been an extraordinary servant to his country and has given us all some wonderful memories as well as being a true gentleman. Thank you Damien and all the best for the future."