Bohemians v UCD, Dalymount Park, 7.45pm
Two of the best young managers in the game, Bohs Aaron Callaghan and UCD’s Martin Russell, go head to head in a game that will feature some of the best up and coming talent in the Airtricity League.
Bohs are without Shane Fitzgerald (ankle), Kevin Devaney (ankle) and Kevin O’Leary (illness).
UCD start the season with two players carrying over suspension and will without the services of both Mick Leahy and Gareth Matthews.
The sides meet again on Monday night in the EA SPORTS Cup.
Bray Wanderers v Shelbourne, Carlisle Grounds, 7.45pm
Both teams have the potential to be this season’s surprise packets and will be keen to get off to a good start.
Bray Wanderers are at full strength which means new signings Eoin Hyland, Conor Earley, Paul Malone and Ismael Akinade are all included in the matchday squad.
Shelbourne have Pat Flynn suspended and a late decision will be made on Glenn Cronin's fitness following an ankle injury which saw him take no part in pre-season games.
Derry City v Sligo Rovers, Brandywell Stadium, 7.45pm
The champions start their title defence with a North West derby and travel full of confidence after last Monday’s 5-0 win over Glentoran in the Setanta Cup.
If Derry are to have any title aspirations they must turn the Brandywell back into a fortress as they lost eight of their 15 home league games last season.
Derry will be without the services of Kevin Deery and Dermot McCaffery who are suspended plus Sean Houston (knee) and Paddy Kavanagh (hamstring).
Danny North (knee ligaments) and Aaron Greene (ankle) will be absent for Rovers. New signing Kieran Djilali is set to make his Sligo debut.
Dundalk v Shamrock Rovers, Oriel Park, 7.45pm
The Stephen Kenny era at Dundalk starts with a home game against the side he parted company with last season, nine months into a three contract.
Trevor Croly is the new man at the helm for Rovers and his side’s 4-1 win over Linfield on Monday night will have done wonders for confidence ahead of this tricky opener.
Dundalk’s Tiarnan Mulvenna has made a full recovery from a hamstring strain while Chris Shields returns after a knee problem.
Rovers Mark Quigley (calf) faces a late fitness test while Sean O’Connor and Ken Oman are both suspended.
St. Patrick's Athletic v Drogheda United, Richmond Park, 7.45pm
Last year’s third plays last year’s second and all eyes are on both sides to see how they react to last season.
St Pat’s finished up without silverware after threatening at one stage to do the double while Drogheda went from relegation candidates at the start of the season to winning the EA Sports Cup, finishing runners-up to Sligo and qualifying for Europe.
St Pat’s goalkeeper Brendan Clarke is set to make his 50th league appearance for the Saints as Dave Ryan has a hand injury while new signing Stephen Maher is suspended.
From Drogheda’s squad of 22, Alan McNally is the only absentee and is expected to be out for at least another month as he recovers from a knee operation.
Live coverage of Limerick City v Cork City on RTÉ Two and RTÉ.ie (RoI only) from 5.05pm on Sunday 10 March. MNS returns on Monday 11 March on RTÉ Two and RTÉ.ie (RoI only) at 7pm.