Connor Sammon will partner Robbie Keane in attack as Ireland take on Spain at Yankee Stadium on Tuesday evening.
The Derby County centre forward came on as a second-half substitute in Friday's victory over the Faroe Islands and was instrumental in setting up Ireland's third goal.
Keane, of course, was the recipient of Sammon's assist as he notched up his hat-trick against the Faroes and now the duo will lead the line in New York in this end-of-season friendly against the world champions.
Everton's Seamus Coleman moves into midfield for the New York clash with Paul McShane slotting into the back four alongside Sean St Ledger, Darren O'Dea and Stephen Kelly.
Coleman will start on the right side of midfield with Jeff Hendrick making his first start for Ireland in the centre of the park. James McCarthy returns from suspension to partner Hendrick, whil Andy Keogh makes up the midfield four.
Ireland starting XI v Spain: Forde, McShane, St. Ledger, O'Dea, kelly, Hendrick, McCarthy, Coleman, Keogh, Keane, Sammon #COYBIG— FAI (@FAIreland) June 10, 2013
James McClean has to settle for a place on the bench for the clash with Spain despite a lively cameo appearance against the Faroes where the Sunderland winger came on in the second half.
Ireland XI v Spain: Forde, McShane, St Ledger, O'Dea, Kelly; Coleman, Hendrick, McCarthy, Keogh; Keane, Sammon.