Barcelona forward Neymar has been ruled out for four weeks with a left foot injury, the club have confirmed.
The 22-year-old Brazilian sustained the problem during Wednesday night's Copa del Rey final defeat to Real Madrid.
"The player sustained a contusion with caused an edema (a swelling) in the fourth metatarsal in his left foot," a statement from Barcelona read. "He will be sidelined for four weeks."
Spain left-back Jordi Alba also suffered an injury blow during the 2-1 loss at the Mestalla. He is expected to be sidelined for three to four weeks after tearing a muscle in his right hamstring.
The pair will therefore miss the bulk of the Catalan club's remaining Primera Division fixtures, with the season ending on 17 May.
Barcelona, third in La Liga heading into the weekend, host Athletic Bilbao on Sunday.
The news will also be a worry for the respective national teams, with hosts Brazil kicking off the World Cup against Croatia on June 12 and defending champions Spain taking on Holland the following day.