Aston Villa v Newcastle
Midfielders Joe Cole and Carlos Sanchez are set to make their competitive Villa debuts. Defender Jores Okore is also in contention after a knee injury but strikers Christian Benteke (Achilles) and Libor Kozak (broken leg) remain sidelined.
Midfielder Siem de Jong is available for Newcastle after a foot injury and will be joined in the squad by loan striker Facundo Ferreyra.
Midfielder Cheick Tiote will sit out once again with a hamstring problem, while central defender Mapou Yanga-Mbiwa picked up a knock in training last week and full-back Davide Santon is out following knee surgery.
Last five league matches: Aston Villa L W L L W; Newcastle L L W L L
Chelsea v Leicester
Goalkeeper Thibaut Courtois could again be selected ahead of veteran Petr Cech for Chelsea, who report no fresh injury problems after striker Didier Drogba shrugged of an ankle problem to make a late substitute appearance in the 3-1 win at Burnley.
Leicester striker Jamie Vardy (thigh) and winger Marc Albrighton (groin) may return - but the game comes too soon for Danny Drinkwater (hamstring) and Matty James (shin).
Summer signing Matthew Upson (foot) is still a couple of weeks short of a return.
Last five league matches: Chelsea L W D W W; Leicester W W W W D
Crystal Palace v West Ham
Palace's caretaker manager Keith Millen will put Scott Dann through a late fitness test as the central defender battles to beat a hip strain.
Adrian Mariappa trained on Thursday following a rib complaint, while Jonny Williams and Jerome Thomas are also fit to return.
Hammers defender James Collins is banned and Joey O'Brien (knee), James Tomkins and Carl Jenkinson (both hamstring) are doubts.
Matt Jarvis (thigh) could figure but Ravel Morrison (groin) is out. Andy Carroll (ankle) is a long-term absentee and boss Sam Allardyce hopes either Enner Valencia or Diafra Sakho will be fit enough to start in attack.
Last five league matches: Crystal Palace W L D D L; West Ham L L W L L
Everton v Arsenal
Everton midfielder Darron Gibson could be back in contention after 10 months on the sidelines with a knee injury.
Right-back Seamus Coleman is fit after hamstring trouble but striker Arouna Kone (knee) and midfielder Bryan Oviedo (leg) are not yet ready and midfielder Ross Barkley (knee) faces a lengthy lay-off.
Arsenal captain Mikel Arteta (ankle) misses out against his former club, while World Cup winners Per Mertesacker, Lukas Podolski and Mesut Ozil could return to the squad.
Forward Yaya Sanogo (hamstring) could feature but full-back Kieran Gibbs (hamstring) and knee injury victims Theo Walcott and Serge Gnabry miss out.
Last five league matches: Everton W L L W D; Arsenal W W W W W
Southampton v West Brom
Shane Long could make his full Southampton debut against his former club after coming off the bench at Liverpool last weekend.
Fellow new signing Florin Gardos (hamstring) is still likely to miss out, with Gaston Ramirez (groin) and Jay Rodriguez (knee) definite absentees. Manager Ronald Koeman has also said goalkeeper Artur Boruc will not be considered for selection.
Defender Joleon Lescott is unlikely to make his Albion debut despite returning to training after a knee injury.
Boss Alan Irvine will give right-back Cristian Gamboa more time to settle but fellow defender Gareth McAuley could figure after a calf problem and record signing Brown Ideye is available. Midfielder James Morrison (knee) remains sidelined.
Last five league matches: Southampton D W W D L; West Brom W L L L D
Swansea v Burnley
Swansea are waiting on international clearance for Argentina defender Federico Fernandez to feature - and even if he is cleared to play he may still not start as manager Garry Monk could opt to name the same side which won at Manchester United.
Leon Britton, Marvin Emnes and Jay Fulton all have knee injuries.
Striker Sam Vokes (knee) remains Burnley's only absentee.
The Clarets have everyone else available, including new signing Stephen Ward, who will compete with Ben Mee for the left-back position and can also operate in midfield.
Last five league matches: Swansea W W L W W; Burnley W W W D L
Hull v Stoke (Sunday)
Hull manager Steve Bruce is expected to make wholesale changes after the Europa League play-off first leg against Lokeren.
Yannick Sagbo serves the second and final game of a domestic ban, while Robert Snodgrass (knee) is a long-term absentee.
Stoke will be without Stephen Ireland after the midfielder sustained a chest injury in training. Defender Robert Huth is expected to overcome a slight knee problem.
Boss Mark Hughes is weighing up whether to hand loan signing Victor Moses a debut. Defender Geoff Cameron and striker Peter Odemwingie are poised to come into the squad after missing last weekend following their World Cup exploits.
Last five league matches: Hull D L L L W; Stoke D L W W L
Tottenham v QPR (Sunday)
Spurs full-back Kyle Naughton will miss the game through suspension, leaving him on the sidelines with Kyle Walker (pelvis) and Vlad Chiriches (back).
Emmanuel Adebayor, Christian Eriksen, Younes Kaboul, Aaron Lennon and Etienne Capoue will return after being rested for Thursday's Europa League clash at AEL Limassol. Tom Carroll has joined Swansea on a season-long loan.
QPR boss Harry Redknapp may hand debuts to Mauricio Isla and Leroy Fer - Isla could come in for Danny Simpson, while Fer may start from the bench. Fellow new recruit Eduardo Vargas is not in contention as he requires a work permit having signed on loan from Napoli.
Last five league matches: Tottenham W W L W W; QPR L W D W L
Sunderland v Man Utd (Sunday)
Billy Jones and Santiago Vergini are available for Sunderland - Jones has had a troublesome hamstring, while fellow defender Vergini is understood to have sat out because of an administrative problem. Midfielder Emanuele Giaccherini (groin) is the only casualty.
United striker Robin van Persie is fully fit and available but midfielders Michael Carrick, Marouane Fellaini and Ander Herrera (all ankle) are out, as is utility man Jesse Lingard (knee).
Antonio Valencia has recovered from a leg problem but defenders Jonny Evans (leg), Luke Shaw (hamstring) and Marcos Rojo (work permit) are unavailable while doubts remain over right-back Rafael (groin).
Last five league matches: Sunderland W W W L D; Man Utd W L W D L
Man City v Liverpool (Monday)
Eliaquim Mangala is unlikely to make his debut for City - the defender is still short of match-fitness. However, defender Pablo Zabaleta could be in line to start and loan midfielder Frank Lampard is available.
Striker Sergio Aguero may not be ready to play 90 minutes while fellow forward Alvaro Negredo (foot) remains out long term.
Reds winger Lazar Markovic and defender Alberto Moreno are in line for debuts but midfielder Adam Lallana is not ready as his rehabilitation from a knee injury nears a conclusion, Jose Enrique will be assessed but Daniel Agger, Jon Flanagan and Oussama Assaidi are out.
Last five league matches: Man City W W W W W; Liverpool W L D W W