The Premier League's top four will all face off in the fifth round of the FA Cup with Manchester City hosting Chelsea and Arsenal taking on Liverpool.
Upon hearing his Chelsea side had been drawn against City, manager Jose Mourinho said: "No problem. If you want to be the best you have to play against the best, so it's good for us. Good experience, good game, big game."
Ten-time cup winners Arsenal are currently out in front in the Premier League and tackle Brendan Rodgers' Liverpool after the top-flight sides ousted Coventry and Bournemouth, respectively.
Holders Wigan produced the shock of the fourth round by beating Crystal Palace 2-1 and next face Ole Gunnar Solskjaer's Cardiff in a match set to take place on the weekend of 15-16 February.
The two lowest-ranking teams remaining in the competition, Sheffield United and Preston of League One, could vie for a place in the quarter-finals if they can get through respective replays against Fulham and Nottingham Forest.
The Blades held Fulham to a 1-1 draw and go to Craven Cottage on 4 February. Preston invite Nottingham Forest to Deepdale for a decider following Friday night's stalemate.
In two remaining all-Premier League clashes, Sunderland - fourth-round victors over non-league Kidderminster - entertain Southampton, and 1995 winners Everton tackle Swansea at Goodison Park.
Hull's victory over Southend earned them a return trip south, this time to Brighton, and two Championship sides will go head-to-head at Hillsborough when Sheffield Wednesday host Charlton.