Hull City v Manchester City, 12:45pm
Strikers Nikica Jelavic and Shane Long will both be pushing for recalls as Hull prepare to face Barclays Premier League title-chasers Manchester City at the KC Stadium.
Jelavic and Long were both cup-tied for the Tigers' FA Cup quarter-final win over Sunderland last week, in which Matty Fryatt and Sone Aluko led the line.
Boss Steve Bruce has no new injury concerns as his side go in search of the first of the two victories he believes will seal their place in the top-flight for at least another season.
Hull squad: McGregor, Harper, Davies, Faye, Bruce, Figueroa, Rosenior, Chester, Huddlestone, Elmohamady, Meyler, Quinn, Livermore, Boyd, Jelavic, Long, Fryatt, Koren, Sagbo, Aluko.
Manchester City are without top scorer Sergio Aguero for their trip to Hull.
The Argentinian was withdrawn at half-time during the Champions League loss at Barcelona in midweek with another hamstring problem.
Fellow striker Stevan Jovetic (hamstring) and defender Matija Nastasic (knee) are also still sidelined, while right-back Micah Richards has suffered a knock.
Manchester City squad: Hart, Pantilimon, Zabaleta, Kompany, Demichelis, Lescott, Boyata, Kolarov, Clichy, Milner, Silva, Nasri, Navas, Fernandinho, Toure, Garcia, Rodwell, Dzeko, Negredo.
Swansea v West Brom, 3pm
Striker Michu could make his comeback from a three-month ankle injury layoff in Swansea's game against West Brom.
Midfielder Jonjo Shelvey and defender Kyle Bartley (both hamstring) are out but goalkeeper Michel Vorm has been cleared to play after overcoming illness.
The Swans will test midfielder Pablo Hernandez (hamstring) on Friday.
Swansea squad: Vorm, Amat, Taylor, Flores, Williams, Britton, Bony, Hernandez, Dyer, Cornell, Lamah, Routledge, Tiendalli, De Guzman, Canas, Rangel, Pozuelo, Tremmel, Vazquez, Richards, Ngog, Emnes, Michu.
West Brom will be without several players for the trip to the Britannia Stadium.
Steven Reid (knee), Claudio Yacob (hamstring) and captain Chris Brunt (knee) will all be absent after coming off in last weekend's 3-0 home defeat to Manchester United, with the latter subsequently being ruled out of action for five to six weeks having sustained medial ligament damage.
Diego Lugano was already sidelined with a similar problem - he faces three to four weeks out - and Billy Jones (hamstring) is not yet ready to return.
Striker Nicolas Anelka will begin his five-match suspension after both he and the Football Association declined to appeal against the sanction imposed over his 'quenelle' goal celebration against West Ham.
West Brom squad: Foster, Myhill, Popov, Olsson, Ridgewell, McAuley, Dawson, Morrison, Sinclair, Dorrans, Amalfitano, Mulumbu, Gera, Sessegnon, Anichebe, Vydra, Berahino, Bifouma.
Everton v Cardiff, 3pm
Everton captain Phil Jagielka faces a late fitness test on a hamstring injury to see whether or not he can return from a fortnight's absence to face Cardiff at home.
Midfielder Steven Pienaar has also to be assessed after coming off with a knock in the FA Cup quarter-final defeat at Arsenal.
Goalkeeper Tim Howard returns after being rested last week.
Provisional squad: Howard, Coleman, Distin, Stones, Baines, Barry, McCarthy, McGeady, Barkley, Osman, Lukaku, Robles, Alcaraz, Hibbert, Browning, Jagielka, Pienaar, Naismith, Mirallas.
Centre-back Ben Turner could be doubtful for relegation-threatened Cardiff's trip to Everton.
The 25-year-old suffered a knock late in the Bluebirds' vital win over Fulham last weekend.
Spanish defender Juan Cala is back in contention after recovering from a stomach bug.
Cardiff squad: Marshall, Lewis, Turner, Theophile-Catherine, Fabio, John, Caulker, Campbell, Daehli, Medel, Eikrem, Mutch, Noone, Kim, Jones, Cala, Bellamy, Zaha, Taylor, Whittingham, Gunnarsson, Cowie, McNaughton.
Fulham v Newcastle, 3pm
Winger Ashkan Dejagah faces a fitness test to determine if he can play for Fulham in Saturday's Premier League home clash with Newcastle after picking up an injury in last week's loss at Cardiff.
Midfielder Georgios Karagounis is out with a muscle strain suffered in south Wales, joining Scott Parker (knee) in the treatment room.
Parker could be back next week, but Damien Duff (knee) is out for the rest of the season.
Fulham squad: Stekelenburg, Stockdale, Heitinga, Hangeland, Riether, Riise, Burn, Sidwell, Richardson, Kacaniklic, Kvist, Bent, Holtby, Kasami, Mitroglou, Dejagah, Woodrow, Zverotic.
Absent Newcastle boss Alan Pardew has been dealt a major blow ahead of the to Fulham.
Pardew has a stadium ban after head-butting David Meyler and will set his team out in advance. Leading scorer Loic Remy is likely to miss the next three games with a calf problem, and he will be joined on the sidelines by full-back Mathieu Debuchy, who has a groin problem and will sit out at least the same period.
Central defender Fabricio Coloccini returns after a family bereavement, but keeper Rob Elliot and full-back Davide Santon (both knee) remain doubts and midfielder Hatem Ben Arfa will not be included because of a family illness.
Newcastle squad: Krul, Alnwick, Coloccini, Williamson, Yanga-Mbiwa, S. Taylor, Dummett, Haidara, Tiote, Anita, Marveaux, Sissoko, Gouffran, Sammy Ameobi, Gosling, Cisse, De Jong, Shola Ameobi, Armstrong.
Southampton v Norwich, 3pm
Jack Cork will miss Southampton's Premier League clash with Norwich and the next few weeks with an ankle complaint.
The midfielder sustained the injury during last weekend's 1-0 win at Crystal Palace and Victor Wanyama, his replacement at Selhurst Park, is a doubt for Saturday's match.
The Kenyan midfielder suffered a blow to the leg he fractured earlier in the campaign and will be assessed on Saturday, while back-up goalkeeper Kelvin Davis is out after also taking a knock in training.
Southampton squad: Boruc, Gazzaniga, Cropper, Chambers, Clyne, Shaw, Targett, Fonte, Lovren, Hooiveld, Yoshida, Reed, Schneiderlin, Wanyama, Ward-Prowse, Lallana, Ramirez, Rodriguez, S Davis, Gallagher, Lambert.
Norwich have no fresh injury concerns.
On-loan winger Jonas Gutierrez (calf) and centre-back Michael Turner (hamstring) returned to first-team training this week and winger Elliott Bennett (knee) will join the group next week as the trio near on-field returns, but the St Mary's trip comes too soon.
Holland midfielder Leroy Fer (hamstring) is in light running, but is weeks away from a return.
Norwich squad: Ruddy, Olsson, Yobo, Bassong, Martin, Tettey, Johnson, Howson, Snodgrass, Redmond, Van Wolfswinkel, Bunn, Hooper, Pilkington, Hoolahan, Elmander, Garrido, Whittaker, R Bennett, Becchio.
Stoke City v West Ham, 3pm
Jon Walters is sidelined along with Stoke team-mate Charlie Adam for Saturday's home clash with West Ham due to suspension.
Both forward Walters and midfielder Adam are serving three-match bans, with the former's beginning this weekend after an appeal against his red card in last Saturday's 1-1 draw at Norwich failed.
Manager Mark Hughes, who is thinking of using a different formation, will make a late call on whether on-loan Liverpool winger Oussama Assaidi (knee) is ready to return to action, and has confirmed defender Robert Huth (knee) will miss the rest of the season.
Stoke squad: Begovic, Sorensen, Shawcross, Wilson, Pieters, Cameron, Muniesa, Shotton, Whelan, Palacios, Ireland, Nzonzi, Crouch, Odemwingie, Wilkinson, Etherington, Guidetti, Arnautovic.
West Ham manager Sam Allardyce has no fresh injury concerns.
Andy Carroll is in line to return to the starting line-up for the first time since his sending off in the 2-0 win over Swansea although fellow forward Marco Borriello remains sidelined with a calf injury.
Joey O'Brien (shoulder) is a long-term absentee while Antonio Nocerino is still looking to make his first Hammers start with full-back Pablo Armero yet to feature since joining in January.
West Ham squad: Adrian, Jaaskelainen, Demel, Tomkins, McCartney, Collins, Johnson, Reid, Armero, Noble, Nocerino, Diame, Taylor, Nolan, J Cole, Downing, Jarvis, Vaz Te, C Cole, Carroll.
Sunderland v Crystal Palace, 3pm
Sunderland boss Gus Poyet has a virtually full-strength squad from which to select for Saturday's vital Barclays Premier League clash with Crystal Palace.
Central defender Wes Brown and midfielder Craig Gardner both missed the 3-0 FA Cup sixth-round defeat at Hull with knocks, but have since returned to training and are in contention.
Striker Jozy Altidore, defender Valentin Roberge and midfielder El-Hadji Ba sat out at the KC Stadium through illness, but all three have recovered, leaving only goalkeeper Keiren Westwood (shoulder) on the sidelines.
Sunderland squad: Mannone, Ustari, Celustka, Alonso, Bardsley, Brown, O'Shea, Vergini, Cuellar, Roberge, Bridcutt, Cattermole, Gardner, Ki, Giaccherini, Johnson, Colback, Larsson, Ba, Mavrias, Altidore, Borini, Scocco, Fletcher.
Crystal Palace manager Tony Pulis will be without Morocco striker Marouane Chamakh.
The 30-year-old, who is the Eagles' top scorer with five league goals, is sidelined with a hamstring strain that already saw him sit out last weekend's 1-0 defeat to Southampton.
English forward Glenn Murray is set to replace Chamakh up front and lead Palace's attack at Sunderland. Pulis will have the rest of his players available for the encounter at the Stadium of Light.
Crystal Palace squad: Speroni, Hennessey, Ward, Gabbidon, Delaney, Dann, Mariappa, Moxey, Parr, Jedinak, Dikgacoi, Bannan, Ledley, Bolasie, Ince, Puncheon, Murray, Gayle, Jerome.
Aston Villa v Chelsea, 5.30pm
Aston Villa will be without on-loan left-back Ryan Bertrand when they face his parent club Chelsea.
The 24-year-old's ineligibility opens the door to Joe Bennett or Antonio Luna, who are competing for his spot in Paul Lambert's XI.
Lambert otherwise has the same squad to pick from as he did last time out against Norwich, with the likes of Jores Okore and Charles N'Zogbia on the long-term injury list.
Aston Villa squad: Guzan, Steer, Clark, Baker, Luna, Vlaar, Bennett, Lowton, Bacuna, El Ahmadi, Albrighton, Westwood, Delph, Sylla, Holt, Tonev, Helenius, Weimann, Agbonlahor, Benteke.
Fernando Torres could be included in Chelsea's squad for the match at Aston Villa as his groin injury was not as bad as was first feared.
The striker withdrew from the starting XI following the warm-up prior to the 4-0 defeat of Tottenham, but could play at Villa Park or be saved for next Tuesday's Champions League contest with Galatasaray.
Defenders David Luiz (groin) and Ashley Cole (knee) remain out.
Chelsea squad: Cech, Ivanovic, Ramires, Lampard, Torres, Oscar, Mikel, Schurrle, Salah, Hazard, Ba, Willian, Matic, Schwarzer, Cahill, Terry, Azpilicueta, Eto'o, Blackman, Kalas.
Manchester United v Liverpool, Sunday 1.30pm
Winger Nani has recovered from a long-term hamstring injury and is available for Manchester United's game against Liverpool on Sunday.
Defender Jonny Evans (calf) and striker Javier Hernandez (knee) are making encouraging progress in their respective rehabilitation programmes and could also feature.
Manager David Moyes must decide whether to stick with Robin van Persie or to recall Danny Welbeck, who scored a fine goal against West Brom last weekend.
Manchester United squad: De Gea, Lindegaard, Rafael, Evra, Ferdinand, Smalling, Jones, Evans, Vidic, Buttner, Giggs, Carrick, Young, Cleverley, Fletcher, Valencia, Kagawa, Nani, Fellaini, Januzaj, Mata, Rooney, Welbeck, Van Persie, Hernandez.
Midfielder Lucas Leiva and defender Mamadou Sakho both return to Liverpool's squad for Sunday's trip to Manchester United.
The pair, sidelined for some time with knee and hamstring injuries respectively, both came through an under-21s game unscathed on Friday and have rejoined the first team.
Forward Raheem Sterling could push for a recall after scoring almost immediately having come off the bench in their last victory at Southampton on March 1.
Liverpool squad: Mignolet, Johnson, Agger, Skrtel, Flanagan, Gerrard, Allen, Henderson, Sterling, Sturridge, Suarez, Jones, Sakho, Cissokho, Toure, Lucas, Alberto, Coutinho, Aspas, Teixeira, Moses.
Tottenham v Arsenal, Sunday 4pm
Tottenham will be without captain Michael Dawson for the north London derby with Arsenal, while Kyle Walker is a major doubt.
A hamstring injury suffered in last weekend's 4-0 defeat at Chelsea will keep centre-back Dawson out of Sunday's match, while a pelvic complaint may well sideline right-back Walker.
Danny Rose (knee) could return to the starting line-up having featured from the bench in Thursday's Europa League loss to Benfica, while Tim Sherwood will be hoping Mousa Dembele is also in contention. Etienne Capoue (ankle), Erik Lamela and Vlad Chiriches (both back) all remain sidelined.
Tottenham squad: Lloris, Friedel, Walker, Naughton, Kaboul, Vertonghen, Rose, Fryers, Sandro, Dembele, Bentaleb, Paulinho, Lennon, Eriksen, Chadli, Townsend, Sigurdsson, Adebayor, Soldado, Kane.
Arsenal will be without midfielder Mesut Ozil for at least three weeks because of a hamstring tear.
Goalkeeper Wojciech Szczesny will return from a midweek European suspension while full-back Nacho Monreal and striker Yaya Sanogo have recovered from foot injuries
Midfielder Kim Kallstrom (back) could be in the squad for the first time. However, defender Kieran Gibbs (calf) remains a doubt, midfielder Aaron Ramsey (thigh) is still a couple of weeks away from full fitness, while Jack Wilshere (foot), Theo Walcott and Abou Diaby (both knee) remain out.
Arsenal squad: Szczesny, Vermaelen, Mertesacker, Koscielny, Sagna, Arteta, Flamini, Cazorla, Oxlade-Chamberlain, Rosicky, Giroud, Fabianski, Podolski, Gnabry, Monreal, Sanogo, Kallstrom, Jenkinson, Gibbs.