For Sunderland, John O'Shea managed to play the full 90 minutes at the weekend on his return from a calf problem and did not suffer a reaction.
Steven Fletcher will again be absent. He missed Saturday's 3-1 defeat by Chelsea with an ankle problem and, although he is making progress, the game is expected to come too soon for him.
Reading will be without Sean Morrison, who picked up an ankle injury against Southampton at the weekend.
Pavel Pogrebnyak will miss out with a knock.
Sunderland squad: Mignolet, Westwood, Bardsley, Kilgallon, O'Shea, Cuellar, Bramble, Rose, Gardner, Colback, McClean, Larsson, Johnson, Vaughan, Sessegnon, Saha, Campbell, Wickham, McFadden.
Reading squad: Federici, Taylor, Cummings, Gorkss, Pearce, Morrison, Mariappa, Shorey, Harte, McAnuff, Guthrie, Leigertwood, Tabb, McCleary, Le Fondre, Hunt, Roberts