European champions Bayern Munich qualified for the last 16 of the Champions League after beating Viktoria Plzen in Group D.
There was no repeat for Bayern of their 5-0 thumping of the Czech side in Munich a fortnight ago, with Mario Mandzukic netting the only goal of the game with a 65th-minute header to maintain his side's 100 per cent record.
Manchester City also progressed from Group D after they punished visitors CSKA 5-2 with an Alvaro Negredo hat-trick and Sergio Aguero double.
It is the first time City have reached the knockout round.
Real Madrid and Paris St Germain both have one foot in the door of the last 16 after they were held to 2-2 and 1-1 draws against Juventus and Anderlecht respectively to end their own hopes of winning every game in the group stages.
At the Juventus Stadium, the Italian side grabbed the lead against Real via a 42nd-minute penalty from Arturo Vidal before Ronaldo and Gareth Bale struck in eight second-half minutes by the hour mark to edge the La Liga side in front.
Fernando Llorentes, however, rescued a point for Juve to leave Real needing only a draw from their remaining two Group B games to guarantee their passage into the knockout phase.
Juve are now bottom, though, with three points after FC Copenhagen pulled off a shock 1-0 home win over Galatasaray, with Daniel Braaten striking the winner after just six minutes.
In Group C, PSG also need only a point from their final two matches, but were forced to come from behind at home to Anderlecht.
Demy de Zeeuw fired the visitors in front in the 68th minute, only for Zlatan Ibrahimovic to haul the hosts level two minutes later.
That was prior to Anderlecht finishing the game with 10 men after Sacha Kljestan was dismissed in the 82nd minute for a second bookable offence.
In Group A both games finished goalless, leaving Manchester United and Bayer Leverkusen as the teams still favourites to qualify.
Shakhtar Donetsk are still in with a chance of finishing in the top two after their 0-0 draw with Leverkusen, a game in which five players were booked.