Simon Zebo has missed out on an Ireland recall after Joe Schmidt announced his 33-man squad for the England RBS 6 Nations clash on Saturday.
The Munster winger had made a successful return from injury, scoring three tries in his last two appearances for the province, but was not named in the extended squad for the game in Twickenham.
His team-mate Dave Kilcoyne has earned a recall in the forwards however, in instead of Cardiff back-row Robin Copeland, as has the fit again Donnacha Ryan, who replaces the injured Dan Tuohy.
Ulster’s Darren Cave and Leinster’s Luke Fitzgerald (groin injury) miss out in the backs but scrum half Isaac Boss is recalled.
Ulster pair Tommy Bowe (groin) and Craig Gilroy are again left out.
Schmidt had signalled he would find it difficult to change a winning team after a successful start to the tournament for Ireland, who can secure their first Triple Crown since 2009 at the weekend.
Rory Best (Banbridge/Ulster)
Sean Cronin (St. Mary's College/Leinster)
Cian Healy (Clontarf/Leinster)
Jamie Heaslip (Dublin University/Leinster)
Iain Henderson (Ballynahinch/Ulster)
Chris Henry (Malone/Ulster)
David Kilcoyne (UL Bohemians/Munster)
Mike McCarthy (Leinster)
Jack McGrath (St. Mary's College/Leinster)
Martin Moore (Lansdowne/Leinster)*
Jordi Murphy (Lansdowne/Leinster)*
Paul O'Connell (Young Munster/Munster)
Tommy O'Donnell (UL Bohemians/Munster)
Peter O'Mahony (Cork Constitution/Munster)
Mike Ross (Clontarf/Leinster)
Rhys Ruddock (St Mary's College/Leinster)
Donnacha Ryan (Shannon/Munster)
Devin Toner (Lansdowne/Leinster)
Isaac Boss (Terenure College/Leinster)
Gordon D'Arcy (Lansdowne/Leinster)
Robbie Henshaw (Buccaneers/Connacht)
Paddy Jackson (Dungannon/Ulster)
Felix Jones (Shannon/Munster)
David Kearney (Lansdowne/Leinster)
Rob Kearney (UCD/Leinster)
Ian Madigan (Blackrock College/Leinster)
Luke Marshall (Ballymena/Ulster)
Fergus McFadden (Old Belvedere/Leinster)
Conor Murray (Garryowen/Munster)
Brian O'Driscoll (UCD/Leinster)
Eoin Reddan (Lansdowne/Leinster)
Jonathan Sexton (Racing Metro 92)
Andrew Trimble (Ballymena/Ulster)
LIVE: RBS 6 NATIONS
Live television coverage of the RBS 6 Nations from 19:30 on Friday 21 February (Wales v France) and 13:00 on Saturday 22 February (Italy v Scotland and England v Ireland) on RTÉ Two and RTE.ie (Ireland only).
Live radio coverage of England v Ireland on Saturday Sport (14:00) on RTÉ Radio 1 and RTÉ.ie (Worldwide).