Fit-again centre Mirco Bergamasco could play for Italy for the first time in more than a year after being included in the squad for next month's Six Nations Championship.
Coach Jacques Brunel has named him in a 30-man selection for their opening two matches against champions Wales in Cardiff on 1 February and France in Paris eight days later.
Bergamasco, 30, fractured a kneecap when he last played for Italy against Australia in Florence in November 2012.
Brunel has also brought in Zebre Rugby fullback Giuglielmo Palazzani for the first time while Benetton Treviso winger Angelo Esposito is awaiting his first start.
Palazzani's Zebre team mate Marco Bortolami will reach 100 caps should he start either of the two games in the second row.
Italy Six Nations squad:
Martin Castrogiovanni, Lorenzo Cittadini, Alberto De Marchi, Michele Rizzo, Leonardo Ghiraldini, Davide Giazzon, Marco Bortolami, Marco Fuser, Quintin Geldenhuys, Antonio Pavanello, Robert Barbieri, Mauro Bergamasco, Paul Derbyshire, Joshua Furno, Sergio Parisse (captain), Alessandro Zanni. Backs: Edoardo Gori, Tobias Botes, Tommaso Allan, Luciano Orquera, Tommaso Benvenuti, Michele Campagnaro, Gonzalo Garcia, Alberto Sgarbi, Mirco Bergamasco, Angelo Esposito, Tommaso Iannone, Luke McLean, Guglielmo Palazzani, Leonardo Sarto.